DECYLUBIQUINONE
- Product Name
- DECYLUBIQUINONE
- CAS No.
- 55486-00-5
- Chemical Name
- DECYLUBIQUINONE
- Synonyms
- DECYLUBIQUINONE;6-decylubiquinone;Decylubiquinone (2,3-Dmdb);2,3-DIMETHOXY-5-METHYL-6-DECYL-1,4-BENZOQUINONE;2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione;2,5-Cyclohexadiene-1,4-dione, 2-decyl-5,6-dimethoxy-3-methyl-
- CBNumber
- CB0262439
- Molecular Formula
- C19H30O4
- Formula Weight
- 322.44
- MOL File
- 55486-00-5.mol
DECYLUBIQUINONE Property
- Boiling point:
- 452.9±45.0 °C(Predicted)
- Density
- 1.02±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 10 mg/ml)
- form
- Neat yellow to orange colored oil.
- color
- Yellow or orange
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D7911
- Product name
- Decylubiquinone
- Purity
- ≥97% (HPLC)
- Packaging
- 10mg
- Price
- $122
- Updated
- 2024/03/01
- Product number
- D7911
- Product name
- Decylubiquinone
- Purity
- ≥97% (HPLC)
- Packaging
- 25mg
- Price
- $242
- Updated
- 2024/03/01
- Product number
- 21027
- Product name
- Decylubiquinone
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $35
- Updated
- 2024/03/01
- Product number
- 21027
- Product name
- Decylubiquinone
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $53
- Updated
- 2024/03/01
- Product number
- D7911
- Product name
- Decylubiquinone
- Purity
- ≥97% (HPLC)
- Packaging
- 100mg
- Price
- $648
- Updated
- 2024/03/01
DECYLUBIQUINONE Chemical Properties,Usage,Production
Description
Decylubiquinone (55486-00-5) inhibits the Ca2+?dependent mitochondrial permeability transition pore (MPTP) without inhibiting respiration.1?Maximum effect on Ca2+?retention capacity of rat liver mitochondria at 100 μM. Inhibits etoposide-induced apoptosis in in L929 cells at 5 μM via inhibition of cytochrome C release.2?Delays rotenone-induced cardiac dysfunction in a zebrafish model of development and cardiovascular function.3?Substrate for various quinone oxidoreductases.4,5
Uses
Decylubiquinone is inhibits the Ca2+-dependent mitochondrial permeability transition pore (MPTP) and also inhibits etoposide-induced apoptosis.
Definition
ChEBI: 6-decylubiquinone is a member of the class of 1,4-benzoquinones that is 2,3-dimethoxybenzoquinone which has been substituted at positions 5 and 6 by decyl and methyl groups. It has a role as a cofactor. It is functionally related to a 6-decylubiquinol.
General Description
Ubiquinone analog.
References
1) Fontaine?et al. (1998),?A Ubiquinone-binding Site Regulates the Mitochondrial Permeability Transition Pore; J. Biol. Chem.,?273?25734 2) Karpinich?et al. (2002),?The course of Etoposide-Induced Apoptosis from Damage to DNA and p53 Activation to Mitochondrial Release of Cytochrome c; J. Biol. Chem.,?277?16547 3) Pinho?et al. (2013)?How mitochondrial dysfunction affects zebrafish development and cardiovascular function: an in vivo model for testing mitochondria-targeted drugs; Br. J. Pharmacol.,?169?1072 4) Kunow?et al.?(1994)?F420H2: quinone oxidoreductase from Archaeoglobus fulgidus. Characterization of a membrane-bound multisubunit complex containing FAD and iron-sulfur clusters; Eur. J. Biochem.,?223?503 5) Zickermann?et al?(1998)?Analysis of the pathogenic human mitochondria mutation ND1/3460 and mutations of strictly conserved residues in it’s vicinity, using the bacterium Paracoccis denitrificans; Biochemistry,?37?11792